Nurse Salary in Missouri 2026: RN, NP, CRNA & Travel Nurse Pay Guide

By Jayson Minagawa, BSN, RN · Unit Manager & MDS Coordinator · Updated June 2, 2026 · BLS May 2025 OEWS + TheCRNA.com 2026 + ZipRecruiter 2026

Missouri sits 15% below the national RN average, which sounds worse than it is once you price a two-bedroom in Kansas City against anything in Boston or Seattle. The state runs a two-market economy: St. Louis anchored by BJC HealthCare — one of the largest nonprofit hospital systems in the country — and Kansas City anchored by Saint Luke's and a growing HCA footprint. ICU nurses here actually average six figures. Travel nurses can start contracts the same week because Missouri is an eNLC compact state. CRNAs at Barnes-Jewish Hospital earn $231,499 and work cases that rival any academic medical center in the Midwest. The significant drag is NP scope of practice: Missouri's collaborative-practice requirements are among the most restrictive in the country, with Senate Bill 562 making partial progress in 2026 but not yet passed.

RN Salary in Missouri: The Two-Market Reality

The BLS May 2025 OEWS puts Missouri's mean RN wage at $85,900/year ($41.30/hr) — roughly 15% below the national mean of $101,420. That gap is real, but so is the cost-of-living differential. St. Louis ranks among the most affordable major metros in the country; Kansas City is similar. A Missouri nurse earning $85,900 takes home more purchasing power than a nurse in Massachusetts earning $117,960 after adjusting for housing costs.

The two main systems define the market. BJC HealthCare dominates St. Louis with 15+ hospitals under the BJC umbrella — Barnes-Jewish Hospital, St. Louis Children's Hospital, Missouri Baptist Medical Center, and Alton Memorial Hospital among them. BJC posts BSN RN wages of $36–$46/hr, with top-of-scale experienced ICU and cardiac nurses reaching the higher end. SSM Health runs a parallel footprint across Missouri and southern Illinois, posting $36–$44/hr. Both systems offer shift differentials (typically $3–$6/hr for nights, $2–$4/hr for weekends) that meaningfully boost base wages for bedside nurses working 12-hour shifts.

Missouri's state income tax tops out at 4.95% — lower than the upper-Midwest average but not the zero-tax advantage of states like Tennessee or Texas. Take-home matters: run the numbers on the pay calculator before accepting an offer that looks competitive on paper.

New graduates can expect to start at $28–$33/hr at most Missouri health systems outside St. Louis. Urban academic centers — Barnes-Jewish, Saint Luke's Kansas City — post new-grad rates of $32–$36/hr depending on unit. Nurses with 5+ years and specialty certification (CCRN, CEN, CNOR) regularly command $44–$52/hr at BSN-preferred facilities.

Travel Nurse Salary in Missouri

Missouri travel nurses averaged $94,862/year posted on ZipRecruiter 2026 — a $9,000 premium over the Missouri staff RN baseline. That gap is narrower than in non-compact states where travel supply is constrained, which is consistent with Missouri's eNLC membership making the state easy to staff from outside.

The compact state advantage is direct: nurses licensed in any of the 40+ eNLC states can work Missouri contracts without obtaining a separate state license. For agencies filling BJC, Mercy, MU Health Care, and HCA-affiliated positions across Missouri, this means faster placement and lower administrative overhead — which partially compresses travel premiums relative to non-compact states like New York or Massachusetts.

ICU and surgical travel contracts at Barnes-Jewish and Saint Luke's consistently post above the Missouri travel average — $58–$72/hr all-in is common for experienced ICU travel nurses working high-complexity cardiac or surgical units. ER travel rates at Mercy and SSM Health facilities statewide run closer to $50–$62/hr depending on census and contract length. Agency stipends (housing, M&IE) apply to Missouri contracts the same as any other state; the taxable base is taxed at Missouri's 4.95% top rate if the nurse establishes Missouri as their tax home.

Nurse Practitioner Salary and Scope of Practice in Missouri

Missouri NPs average $124,600/year ($59.90/hr) — below the national NP mean and reflecting the structural cost of one of the most restrictive APRN practice environments in the country. Under Missouri RSMo Section 334.104, every APRN must maintain a written collaborative practice arrangement with a physician. That physician must review a minimum of 10% of the APRN's charts every 14 days. The collaborative agreement must be renewed annually. And one physician cannot supervise more than six full-time-equivalent APRNs.

The practical impact: NPs in private practice pay $5,000–$15,000/year to maintain collaborating physician relationships. Independent NP-owned primary care practices are difficult to capitalize in Missouri because the collaborating physician requirement creates both cost and operational dependency. Missouri NPs cannot independently prescribe Schedule II controlled substances — hydrocodone is the one Schedule II exception explicitly carved out in statute, but standard controlled substance prescribing authority requires the collaborative arrangement.

Senate Bill 562 (2026) — a bipartisan bill from Sens. Patty Lewis (D-Kansas City) and Nick Schroer (R-St. Charles) — would allow NPs who have logged 2,000 documented hours with a collaborating physician to independently prescribe controlled substances. As of March 2026, the bill was in the Senate's Emerging Issues and Professional Registration Committee. The Missouri State Medical Association opposes the bill, arguing that collaborative agreements protect patients and provide clinical mentorship. Sen. Lewis has noted that restrictive laws are causing Missouri NPs to relocate to neighboring full-practice-authority states, reducing primary care access in rural areas.

For NPs evaluating Missouri positions: large health systems (BJC, SSM, Mercy) function as the de facto collaborating entity and absorb the administrative burden, which is why employed NPs at academic medical centers earn at or near the $124,600 state average. The collaborative requirement hurts independent practitioners hardest — not nurses in employed system roles.

CRNA Salary in Missouri

Missouri CRNAs average $231,499/year per TheCRNA.com 2026 data. That figure sits below the national CRNA median of $248,320 (BLS May 2025 OEWS) but reflects a state where CRNA independence is unconstrained — CRNAs in Missouri practice under their own licensure in acute care settings without the collaborative-practice restrictions that govern NPs.

Barnes-Jewish Hospital in St. Louis is the anchor CRNA employer and the driver of Missouri's top-end CRNA wages. Barnes-Jewish runs one of the busiest cardiac surgery programs in the Midwest (ranked nationally for heart failure and cardiac surgery), a robust solid organ transplant program, and complex neurosurgical cases from Washington University School of Medicine — the academic medical school partner. High-complexity case mix translates to CRNA pay at or above $250,000 for experienced providers taking call. Saint Luke's Health System in Kansas City is the other primary high-pay CRNA employer, with cardiac and vascular surgery volume that commands top-quartile CRNA compensation.

Rural and critical-access hospital CRNA positions across Missouri pay less than the academic medical center tier but offer schedule flexibility and reduced acuity. Locum CRNAs working Missouri travel assignments typically see $140–$180/hr depending on site and call requirements.

ICU and ER Nurse Salary in Missouri

Missouri ICU nurses average $101,946/year ($49.01/hr) — a 19% premium over the state RN mean and the number that matters most for high-acuity bedside nurses. The state doesn't have ratio laws, so ICU census management is entirely at the discretion of hospital administration. Despite that, Barnes-Jewish and Saint Luke's ICUs maintain competitive census management because losing experienced CCRN-certified nurses is expensive — both systems pay meaningfully above the state ICU average for experienced travelers and staff to keep specialized units appropriately staffed.

ER nurses average $81,360/year ($39.12/hr) — slightly below the Missouri RN state mean, consistent with the national pattern where ER base wages trail ICU and OR specialties. Missouri Level I Trauma Centers (Barnes-Jewish, University of Missouri Health Care in Columbia) post ER wages that exceed the state average; community EDs in rural Missouri run below it. If you're a travel nurse targeting Missouri ER contracts, filter for Level I and Level II centers — the acuity-based pay differentials are real.

Major Hospital Systems: St. Louis vs. Kansas City

Missouri's nursing market is geographically concentrated in two metros 250 miles apart, with a small academic medical center in Columbia (MU Health Care) connecting them along I-70.

Ranges based on ZipRecruiter 2026 and Indeed employer posting data. BSN RN mid-career rates. New graduates start at the lower end; experienced specialty-certified nurses reach higher end or above.

One important note on Kansas City geography: The University of Kansas Hospital — technically in Kansas City, Kansas — draws heavily from the Missouri nursing labor pool and is often the highest-paying hospital accessible to Kansas City, MO-based nurses. University of Kansas is a Level I Trauma Center and NCI-designated cancer center that competes directly with Missouri-side systems for clinical staff. Nurses living in Missouri working across the state line at KU Medical Center pay Kansas income tax (5.7% top rate in 2026 — higher than Missouri's 4.95%).

Missouri Is an eNLC Compact State

Missouri joined the enhanced Nurse Licensure Compact and issues multistate licenses to qualifying nurses. The practical implication: if your primary state of residence is any of the 40+ compact states, your existing multistate license lets you practice in Missouri — no endorsement application, no processing wait, no additional fee beyond the license you already hold.

For travel nurses, this makes Missouri one of the easier states to place. Agencies filling BJC, Mercy, and SSM Health positions can activate contracts as soon as credentialing clears — typically 2–4 weeks — rather than waiting 8–12 weeks for a standalone license endorsement. In a market where travel agencies compete on placement speed, compact status is a real operational advantage.

Missouri nurses benefit from the same compact reciprocity when working in neighbor states. Kansas, Iowa, Nebraska, Tennessee, Arkansas, and Oklahoma are all eNLC members. Nurses living near state borders — particularly the Kansas City metro — regularly work shifts in both states on a single multistate license. If you move to Missouri from a non-compact state (Illinois and California are the most common origin markets), you'll apply for a Missouri RN license and receive a multistate license automatically if Missouri becomes your primary residence.

The compact license map tool on this site shows current compact member states and lets you check reciprocity combinations before accepting any out-of-state contract.

Frequently Asked Questions